Chronic kidney disease of unknown cause (CKDu) in disadvantaged communities in low- and middle-income countries

There is an epidemic of primarily tubular-interstitial chronic kidney disease (CKD) clustering in agricultural communities in low-and-middle income countries. Because it is currently unclear whether the etiology is single or multifactorial; this pathology has been classified as CKD of unknown cause (CKDu). Due to the large number of premature deaths attributable to CKDu, it is necessary to know, understand and determine its existence in our country.

Objective

To determine the distribution of the glomerular filtration rate (GFR) and to estimate the prevalence of low GFR (<60 ml / min / 1.7 m2) in a random sample of participants in the Tumbes region.

Design:

This study will have two stages: 1) a cross-sectional study to determine the GFR using different methods (serum creatinine calculated with the formula CKD-EPI and cystatin C; and 2) validation of the iohexol test for estimation of GFR.

Results

The Project has begun on August 2017

Contact

Antonio Bernabe-Ortiz
Antonio.bernabe@upch.pe

Location

Tumbes, Perú

Funding

Medical Research Council (MRC).

Duration

2017 – 2018

Research team

Antonio Bernabe-Ortiz, MD, MPH, Universidad Peruana Cayetano Heredia, CRONICAS Centro de Excelencia en Enfermedades Crónicas.
J Jaime Miranda, MD, MsC, PhD, Universidad Peruana Cayetano Heredia, CRONICAS Centro de Excelencia en Enfermedades Crónicas.
Andrea Ruiz-Alejos, MD, Universidad Peruana Cayetano Heredia, CRONICAS Centro de Excelencia en Enfermedades Crónicas .

Contributors: Neil Pearce y Liam Smeeth (London School of Hygiene and Tropical Medicine).
Ben Caplin (University College London).

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