Household Air Pollution and Health (HAPIN): a multi-country LPG intervention trial

In Low and Middle income countries (LMICs), indoor pollution is produced by the use of fossil fuels. Air pollution has been associated with negative outcomes in health such as; respiratory infections in children, and heart attack, stroke, chronic obstructive pulmonary disease and lung cancer in adults.


This study aims to evaluate the impact of the improvement of changing from fossil fuels to liquefied petroleum gas (LPG) functioning kitchens on health of pregnant women, children and adult women in four different countries (India, Guatemala, Peru and Rwanda). Secondary objectives of the project are: 1) by using intention to treat analysis, assess the impact of the intervention on health, 2) assess the exposure to air pollution curves and response in health on four different populations from LMIC, and 3) assess the relationship between biomarkers of exposure to air pollution and health biomarkers.


Randomized controlled trial.


This project has started in 2016.


J. Jaime Miranda, MD, MSc, PhD


India, Guatemala, Peru, Rwanda.


National Institutes of Health, USA
National Heart, Lung and Blood Institute


2016 – 2021

Research team

J. Jaime Miranda, CRONICAS, Universidad Peruana Cayetano Heredia.
Maria Kathia Cárdenas, CRONICAS, Universidad Peruana Cayetano Heredia.

Contributors: Sri Ramachandra University, India.
London School of Hygiene & Tropical Medicine, UK.
Washington University, USA.
Asociación Benéfica PRISMA, Perú.
Universidad Peruana Cayetano Heredia, Perú.
Universidad del Valle, Guatemala.
University of Georgia, USA.
Harvard University, USA.
Berkeley Air Quality Monitoring and the University of California San Francisco, USA.
Colorado State University, USA.
Johns Hopkins University, USA.
Emory University, USA.